منابع مشابه
UnTEThering (smooth muscle) cell plasticity.
C ellular plasticity has become the subject of intense research, with perhaps the greatest example provided by the recent Nobel Prize winners Drs Yamananka and Gurdon and the demonstration that terminally differentiated fibro-blasts can be coaxed into assuming an embryonic stem cell-like fate. Emerging evidence suggests that plasticity inherent in cells may be hijacked in the progression of dis...
متن کاملUnTEThering ( Smooth Muscle ) Cell Plasticity Running title :
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متن کاملSmooth muscle cell plasticity: fact or fiction?
University of Virginia, Cardiovascular Research Center, Charlottesville, VA 22908; 2 Aab Cardiovascular Research Institute, University of Rochester School of Medicine & Dentistry, Rochester, NY 14642; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane 4072, Australia; Department of Surgery, University of Washington School of Medicine, Seattle, WA 9819...
متن کاملVascular smooth muscle cell phenotypic plasticity: focus on chromatin remodelling.
Differentiated vascular smooth muscle cells (SMCs) retain the capacity to modify their phenotype in response to inflammation or injury. This phenotypic switching is a crucial component of vascular disease, and is partly dependent on epigenetic regulation. An appreciation has been building in the literature for the essential role chromatin remodelling plays both in SMC lineage determination and ...
متن کاملPlasticity in canine airway smooth muscle
The large volume changes of some hollow viscera require a greater length range for the smooth muscle of their walls than can be accommodated by a fixed array of sliding filaments. A possible explanation is that smooth muscles adapt to length changes by forming variable numbers of contractile units in series. To test for such plasticity we examined the muscle length dependence of shortening velo...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2013
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.112.281048